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Aspirin works by irreversibly inhibiting COX 1 mediated synthesis of thromboxane A2, and is used to inhibit platelet aggregation. Age adjusted death rates per 10000 person years across incremental thirds of muscular strength were 38.9, 25.9, and 26.6 for all causes; 12.1, 7.6, and 6.6 for cardiovascular disease; and 6.1, 4.9, and 4.2 for cancer (all PConclusion Muscular strength is inversely and independently associated with death from all causes and cancer in men, even after adjusting for cardiorespiratory fitness and other potential confounders.IntroductionThe role of muscular strength in the performance of activities of daily living and exercise, as well as in the prevention of chronic disease, is increasingly being recognised.1 2 Resistance exercise training increases muscular strength and is currently prescribed by major health organisations for improving health and fitness.3 4 5 6 Likewise, cardiorespiratory fitness provides strong and independent prognostic information about the overall risk of illness and death in adults across a broad spectrum of ages.7 8 9 10 11 12 13 This applies to apparently healthy people and to those with diabetes mellitus, hypertension, metabolic syndrome, and several types of cancer.14Several prospective studies have shown that muscular strength is inversely associated with all cause mortality.15 16 17 18 19 20 21 22 23 24 25 26 27 All but two of these studies18 26 assessed strength through a handgrip test, which involves relatively small muscle groups.
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