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An Overview Of The Applications Of Liposomes An Overview Of The Applications Of Liposomes April 15 [url=http://www.basketheartpatent.fr/puma-basket-heart-denim.html]puma heart denim bleu[/url] , 2013 | Author: Camille Nicholson | Posted in Education
Liposomes are artificial lipid vesicles that are spherical in shape. They are produced from cholesterol and natural phospholipids. They can either be multilamellar (with many bilayers) or unilamellar (with one bilayer). They consist of concentric phospholipid bilayers enclosing aqueous compartments. They are used to encapsulate hydropihilic molecules dissolved in aqueous solutions. Clodronate is a non- toxic bisphosphonate usually developed for the purpose of human application.
They entrap DNA by two mechanisms and are classified as either cationic or pH-sensitive. Cationic are charged positively and interact with DNA molecules of a negative charge to form a strong complex. These liposomes contain a positively charged lipid and helper lipid (co-lipid). The co-lipids or helper lipids play an important role in stabilizing the resulting liposome complex. Some of the positively charged lipid formulations such as lipofectin are found in the market. The complexes facilitate the process of gene transfer.
A pH sensitive liposome has a negative charge and usually captures the DNA molecule and no complex is formed. This is due to the different charges on the lipid and the DNA molecule which repel each other. They are not able to function well in low pH since they are destabilized by it. To ensure effective functioning of these liposomes, it is important to ensure there is interference from serum proteins and toxins.
They offer a number of advantages in the process of delivering genes to cells. They have the ability to form complexes with both positively and negatively charged molecules. They ensure the DNA molecules are well protected from degradative processes. They allow for the transfer of large molecules almost the size of chromosomes and it is possible to target them to specific tissues or cells. In addition, they overcome problems arising from viral vectors.
Besides their usefulness in drug and gene delivery, they are effective carriers of dyes to textiles, pesticides to plants, cosmetics to the human skin, enzymes and beneficial nutrients to foods. In nano cosmetology [url=http://www.basketheartpatent.fr/puma-fenty-bow.html]puma fenty bow rose[/url] , they are very useful since they possess a number of suitable characteristics. These include prolonged release time, high rates of diffusion and penetration of active elements, increased biocompatibility, more stability and their ability to reduce negative side effects.
The can be manufactured in a number of ways. In order to ensure those manufactured are effective, there are factors that are put into consideration. It is important to consider the physiochemical properties of the entrapped medium and liposomal ingredients, the concentration and toxicity and the medium of lipid dispersion. The effect of additional processes involved in its application has to be taken into account
Their size, lipid composition and lamellarity influence properties such as permeability [url=http://www.basketheartpatent.fr/femme-puma-basket-suede-heart-reset-sneakers-chaussures-prism-rose-363229-02.html]puma suede heart reset rose[/url] , fluidity, structure and stability. These factors can be customized to suit specific requirements. They are also influenced by external factors like ionic strength, temperature and the presence of certain molecules in their vicinity.
Liposomes are used in various biotechnological applications. Research is underway to determine other areas where it can be applied. The current increasing interest in liposomes in numerous scientific disciplines together with their application in immunology, medicine, cosmetic ecology, diagnostics, food and the cleansing industry are very promising. In the medical field [url=http://www.basketheartpatent.fr/femme-puma-basket-suede-heart-reset-sneakers-chaussures-aruba-bleu-aruba-bleu-363229-01.html]puma suede heart reset bleu[/url] , they are used to protect and deliver therapeutic agents into the body or to specific cells of the body.
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How To Excel With A Denver Personal Life Coach How To Excel With A Denver Personal Life Coach October 17, 2014 | Author: Samital Leah Zerna | Posted in Business
Maybe you are not working at the job of your dreams, and your home may be nothing like you want it to be. In fact, maybe nothing seems to be going right for you these days. It may be time to consider professional assistance from Denver personal life coaching.
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Your coach is there to assist you with personal matters also. You and your spouse may be fighting frequently and thinking of going your separate ways. A coach will help you explore all options, so you do not make ha.